L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity

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Torrente, Angelo | Mesirca, Pietro | Neco, Patricia | Rizzetto, Riccardo | Dübel, Stefan | Barrère, Christian | Sinegger-Brauns, Martina | Striessnig, Joerg | Richard, Sylvain | Nargeot, Joël | Gómez, Ana María | Mangoni, Matteo E.

Edité par CCSD ; Oxford University Press (OUP) -

International audience. Sino-atrial node (SAN) automaticity is an essential mechanism of heart rate generation that is still not completely understood. Recent studies highlighted the importance of intracellular Ca(2+) ([Ca(2+)]i) dynamics during SAN pacemaker activity. Nevertheless, the functional role of voltage-dependent L-type Ca(2+) channels in controlling SAN [Ca(2+)]i release is largely unexplored. Since Cav1.3 is the predominant L-type Ca(2+) channel isoform in SAN cells, we studied [Ca(2+)]i dynamics in isolated cells and ex vivo SAN preparations explanted from wild-type (WT) and Cav1.3 knockout (KO) mice (Cav1.3(-/-)).

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