Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance

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Bei, Amy K. | Niang, Makhtar | Deme, Awa B. | Daniels, Rachel F. | Sarr, Fatoumata D. | Sokhna, Cheikh | Talla, Cheikh | Faye, Joseph | Diagne, Nafissatou | Doucoure, Souleymane | Mboup, Souleymane | Wirth, Dyann F. | Tall, Adama | Ndiaye, Daouda | Hartl, Daniel L. | Volkman, Sarah K. | Toure-Balde, Aissatou

Edité par CCSD ; Oxford University Press -

International audience. Dramatic changes in transmission intensity can impact Plasmodium population diversity. Using samples from 2 distant time-points in the Dielmo/Ndiop longitudinal cohorts from Senegal, we applied a molecular barcode tool to detect changes in parasite genotypes and complexity of infection that corresponded to changes in transmission intensity. We observed a striking statistically significant difference in genetic diversity between the 2 parasite populations. Furthermore, we identified a genotype in Dielmo and Ndiop previously observed in Thies, potentially implicating imported malaria. This genetic surveillance study validates the molecular barcode as a tool to assess parasite population diversity changes and track parasite genotypes.

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