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Rapid emergence ofFKSmutations inCandida glabrataisolates in a peritoneal candidiasis

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Sasso, Milène | Roger, Claire | Lachaud, Laurence

Edité par CCSD ; [Amsterdam] : Elsevier -

International audience. We report a rapid acquisition of echinocandin resistance after 12 days of micafungin treatment, without prior exposure, in a patient with peritoneal candidiasis due toC. glabrata. Isolates recovered before and after treatment were compared by multilocus sequence typing. Results of antifungal susceptibility testing andFKSmutations were reported. The interest of repeating antifungal susceptibility testing for echinocandin molecules during the treatment is discussed and a strategy to researchFKSmutations proposed.

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