Syracuse

Adult intramedullary gliomas

Archive ouverte

Campello, C. | Parker, F. | Slimani, S. | Le Floch, A. | Herbrecht, A. | Aghakhani, N. | Lacroix, C. | Loiseau, H. | Lejeune, J. P. | Perrin, Gilles | Honnorat, J. | Dufour, H. | Chinot, O. | Figarella, D. | Bauchet, L. | Duffau, H. | Lonjon, M. | Labauge, Pierre | Messerer, M. | Daures, J. P. | Fabbro, P. | Ducot, B.

Edité par CCSD ; Elsevier Masson -

International audience. Intramedullary gliomas are rare tumors accounting for less than 4% of all primary central nervous system tumors. The aims of this retrospective multicenter study were to assess their natural outcome as well as management. METHODS AND MATERIALS: We studied 332~patients from 1984~to 2011. Histopathological examination revealed 72% ependymomas (94% were low grade tumors), 24% astrocytomas (29% were high grade tumors), 2.4% mixed gliomas and 1.7% oligodendrogliomas. RESULTS: The mean age at diagnosis was 42.4~years for ependymomas, with male predominance, versus 39.6~years for astrocytomas. Pain was the most common initial presentation. In 20% of cases, astrocytomas were biopsied alone, but more than 80% of ependymomas had surgical resection. Radiotherapy and chemotherapy were reserved for malignant tumors, especially if they were ependymomas. The 5-year survival rate was 76.8% for astrocytomas and 94.5% for ependymomas. Histology, functional status prior to surgery, and tumor grade are among the prognostic factors. CONCLUSION: Our study showed that surgical treatment of gliomas is well codified, at least for ependymomas, but adjuvant treatment continues to play a marginal role in the management even in astrocytomas, which are infiltrative tumors.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion