Circulating tumour cells as a potential screening tool for lung cancer (the AIR study): protocol of a prospective multicentre cohort study in France

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Leroy, Sylvie | Benzaquen, Jonathan | Mazzetta, Andrea | Marchand-Adam, Sylvain | Padovani, Bernard | Israël-Biet, Dominique | Pison, Christophe, M. | Chanez, Pascal | Cadranel, Jacques | Mazières, Julien | Jounieaux, Vincent | Cohen, Charlotte | Hofman, Véronique | Ilie, Marius | Hofman, Paul | Marquette, Charles Hugo

Edité par CCSD ; BMJ Publishing Group -

International audience. Lung cancer (LC) is the leading cause of death from cancer. Early diagnosis of LC is of paramount importance in terms of prognosis. The health authorities of most countries do not accept screening programmes based on low-dose chest CT (LDCT), especially in Europe, because they are flawed by a high rate of false-positive results, leading to a large number of invasive diagnostic procedures. These authorities advocated further research, including companion biological tests that could enhance the effectiveness of LC screening. The present project aims to validate early diagnosis of LC by detection and characterisation of circulating tumour cells (CTCs) in a peripheral blood sample taken from a prospective cohort of persons at high-risk of LC.

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