GLOBAL MOTOR UNIT NUMBER INDEX SUM SCORE FOR ASSESSING THE LOSS OF LOWER MOTOR NEURONS IN AMYOTROPHIC LATERAL SCLEROSIS

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Grimaldi, Stephan | Duprat, Laureline | Grapperon, Aude-Marie | Verschueren, Annie | Delmont, Emilien | Attarian, Shahram

Edité par CCSD ; Wiley -

International audience. Introduction: We propose a motor unit number index (MUNIX) global sum score in amyotrophic lateral sclerosis (ALS) to estimate the loss of functional motor units. Methods: MUNIX was assessed for 18 ALS patients and 17 healthy controls in 7 muscles: the abductor pollicis brevis (APB), abductor digiti minimi (ADM), tibialis anterior (TA), deltoid, trapezius, submental complex, and orbicularis oris. Results: MUNIX was significantly lower in ALS patients than in healthy controls for the APB, ADM, TA, and trapezius muscles. The MUNIX sum score of 4 muscles (ADM + APB + trapezius + TA) was lower in ALS patients (P=0.01) and was correlated with clinical scores. Discussion: The global MUNIX sum score proposed in this study estimates the loss of lower motor neurons in several body regions, including the trapezius, and is correlated with clinical impairment in ALS patients.

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