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Site‐Specific Isotopic Labeling (SSIL) – Access to High‐Resolution Structural and Dynamic Information in Low Complexity Proteins

Archive ouverte | Urbanek, Annika, N | CCSD

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Flanking regions determine the structure of the poly-glutamine homo- repeat in huntingtin through mechanisms common among glutamine-rich human proteins

Archive ouverte | Urbanek, Annika, N | CCSD

International audience. The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich region (...

Evidence of the reduced abundance of proline cis conformation in protein poly-proline tracts

Archive ouverte | Urbanek, Annika, N | CCSD

International audience. Proline is found in a cis conformation in proteins more often than other proteinogenic amino acids, where it influences structure and modulates function, being the focus of several high-resol...

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