Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

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Avercenc-Leger, Léonore | Guerci, Philippe | Virion, Jean-Marc | Cauchois, Ghislaine | Hupont, Sebastien | Rahouadj, Rachid | Magdalou, Jacques | Stoltz, Jean-Francois | Bensoussan, Danièle | Huselstein, Céline | Reppel, Loïc

Edité par CCSD ; BioMed Central -

International audience. Background: The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available for MSC isolated from Wharton's jelly (WJ-MSC). We initiated a study to identify whether obstetric factors influenced MSC properties. We aimed to evaluate the correlation between a large number of obstetric factors collected during pregnancy and until peripartum (related to the mother, the labor and delivery, and the newborn) with WJ-MSC proliferation and chondrogenic differentiation parameters.

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