Afficher la couverture 'AIDing-targeted protein degradation in Drosophila | Zhang, Xu' en grand format
/5

0 avis

AIDing-targeted protein degradation in Drosophila

Archive ouverte

Zhang, Xu | Schnorrer, Frank

Edité par CCSD ; Wiley -

International audience. Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).

Consulter en ligne

Suggestions

Du même auteur

CHRAC/ACF contribute to the repressive ground state of chromatin

Archive ouverte | Scacchetti, Alessandro | CCSD

International audience. The chromatin remodeling complexes chromatin accessibility complex and ATP-utilizing chromatin assembly and remodeling factor (ACF) combine the ATPase ISWI with the signature subunit ACF1. Th...

A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

Archive ouverte | Spletter, Maria | CCSD

International audience. Muscles organise pseudo-crystalline arrays of actin, myosin and titin filaments to build force-producing sarcomeres. To study sarcomerogenesis, we have generated a transcriptomics resource of...

Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono

Archive ouverte | Zhang, Xu | CCSD

International audience. Muscle morphogenesis is a multi-step program, starting with myoblast fusion, followed by myotube-tendon attachment and sarcomere assembly, with subsequent sarcomere maturation, mitochondrial ...

Chargement des enrichissements...