Syracuse

Anti-Mi2 dermatomyositis revisited: pure DM phenotype with muscle fiber necrosis and high risk of malignancy

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Landon-Cardinal, O. | Monseau, G. | Schoindre, Y. | Rigolet, A. | Champtiaux, N. | Hervier, B. | Masseau, A. | Hachulla, E. | Papo, T. | Terrier, B. | Meyer, A. | Maurier, F. | Gaches, F. | Salort-Campana, Emmanuelle | Audia, S. | Bouvier, A. | Stenzel, W. | Benveniste, O. | Bienvenu, B. | Allenbach, Y.

Edité par CCSD -

IF 2.969. International audience. Anti-Mi2 are dermatomyositis-specific autoantibodies (Aabs) that have been associated, in small cohorts, with a good prognosis possibly related to a lower malignancy risk. Our objective was to describe the phenotype of anti-Mi-2 dermatomyositis (DM) in a larger cohort. A national multicenter retrospective cohort study was performed including all patients with a clinical phenotype suggestive of DM (cutaneous manifestations and/or muscle involvement) and a positive anti-Mi2 Aabs. Medical records were retrospectively reviewed to assess clinical and histological features, and presence of cancer occurring ± 3 years of diagnosing myositis (CAM).

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