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Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6

Archive ouverte | Acosta Lopez, Manuel | CCSD

International audience. Coenzyme Q (CoQ), a redox-active lipid, is comprised of a quinone group and a polyisoprenoid tail. It is an electron carrier in the mitochondrial respiratory chain, a cofactor of other mitoch...

Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency.

Archive ouverte | Salviati, Leonardo | CCSD

International audience. BACKGROUND: COQ4 encodes a protein that organises the multienzyme complex for the synthesis of coenzyme Q(10) (CoQ(10)). A 3.9 Mb deletion of chromosome 9q34.13 was identified in a 3-year-old...

COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells

Archive ouverte | Pelosi, Ludovic | CCSD

International audience. Coenzyme Q (CoQ) is a redox lipid that fulfills critical functions in cellular bioenergetics andhomeostasis. CoQ is synthesized by a multi-step pathway that involves several COQ proteins. Two...

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