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Divergent transcription is associated with promoters of transcriptional regulators.

Archive ouverte | Lepoivre, Cyrille | CCSD

International audience. BACKGROUND: Divergent transcription is a wide-spread phenomenon in mammals. For instance, short bidirectional transcripts are a hallmark of active promoters, while longer transcripts can be d...

Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation

Archive ouverte | Cauchy, Pierre | CCSD

International audience. Ets1 is a sequence-specific transcription factor that plays an important role during hematopoiesis, and is essential for the transition of CD4(-)/CD8(-) double negative (DN) to CD4(+)/CD8(+) ...

Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

Archive ouverte | Koch, Frederic | CCSD

International audience. Recent work has shown that RNA polymerase (Pol) II can be recruited to and transcribe distal regulatory regions. Here we analyzed transcription initiation and elongation through genome-wide l...

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