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Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

Archive ouverte | Roquilly, Antoine | CCSD

International audience. Sepsis and trauma cause inflammation and elevated susceptibility to hospital-acquired pneumonia. As phagocytosis by macrophages plays a critical role in the control of bacteria, we investigat...

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

Archive ouverte | Chaumette, Tanguy | CCSD

International audience. Rationale: Brain injury induces systemic immunosuppression, increasing the risk of viral reactivations and altering neurological recovery.Objectives: To determine if systemic immune alteratio...

Interleukin-22 regulates interferon lambda expression in a mice model of pseudomonas aeruginosa pneumonia

Archive ouverte | Broquet, Alexis | CCSD

International audience. Background:Interleukin (IL)-22 is a cytokine involved in tissue protection and repair following lung pathologies.Interferon (IFN)-λcytokines displayed similar properties during viral infectio...

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