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Cefazolin versus anti-staphylococcal penicillins for treatment of methicillin-susceptible Staphylococcus aureus bacteraemia: a narrative review

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Loubet, Paul | Burdet, Charles | Vindrios, William | Grall, Nathalie | Wolff, Michel | Yazdanpanah, Yazdan | Andremont, Antoine | Duval, Xavier | Lescure, François-Xavier

Edité par CCSD ; Elsevier for the European Society of Clinical Microbiology and Infectious Diseases -

International audience. Anti-staphylococcal penicillins (ASPs) are recommended as first-line agents in methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. Concerns about their safety profile have contributed to the increased use of cefazolin. The comparative clinical effectiveness and safety profile of cefazolin versus ASPs for such infections remain unclear. Furthermore, uncertainty persists concerning the use of cefazolin due to controversies over its efficacy in deep MSSA infections and its possible negative ecological impact.

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