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Structure-function studies of the Kir6.2 channel and of its coupling with natural and artificial partners. Etude structure-fonction du canal Kir6.2 et de son couplage avec des partenaires naturels et artificiels

Archive ouverte | Principalli, Maria Antonietta | CCSD

ATP-sensitive potassium (K-ATP) channels play a key role in adjusting the membrane potential to the metabolic state of cells. They result from the unique combination of two proteins: the SulfonylUrea Receptor (SUR), a protein of t...

Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues

Archive ouverte | Principalli, Maria Antonietta | CCSD

International audience. ATP-sensitive potassium channels (K-ATP channels) play a key role in adjusting the membrane potential to the metabolic state of cells. They result from the unique combination of two proteins:...

The ligand-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules

Archive ouverte | Lemel, Laura | CCSD

International audience. Cholesterol is a major component of mammalian plasma membranes that affects the physical properties of the lipid bilayer but also the function of many membrane proteins including G protein-co...

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