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Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis

Archive ouverte | Millet, Virginie | CCSD

International audience. Objective In the management of patients with IBD, there is a need to identify prognostic markers and druggable biological pathways to improve mucosal repair and probe the efficacy of tumour n...

Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.

Archive ouverte | Pouyet, Laurent | CCSD

International audience. BACKGROUND:: Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal...

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity

Archive ouverte | Giessner, Caroline | CCSD

International audience. Like other tumors, aggressive soft tissue sarcomas (STS) use glycolysis rather than mitochondrial oxidative phosphorylation (OXPHOS) for growth. Given the importance of the cofactor coenzyme ...

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