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Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats

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Ayme-Dietrich, Estelle | Marzak, Halim | Lawson, Roland | Mokni, Walid | Wendling, Olivia | Combe, Roy | Becker, Julien | El Fertak, Lahcen | Champy, Marie-France | Matz, Rachel | Andriantsitohaina, Ramaroson | Doly, Stéphane | Boutourlinsky, Katia | Maroteaux, Luc | Monassier, Laurent

Edité par CCSD ; Lippincott, Williams & Wilkins -

International audience. Left-ventricular hypertrophy and interstitial fibrosis are the main pathophysiological factors of heart failure with preserved ejection fraction. Blockade of the serotonin 5-HT2B receptor (5-HT2BR) has been shown to reduce cardiac hypertrophy, oxidative stress, and extracellular cell matrix activation. In this study, we evaluated the effects of the 5-HT2BR blockade, on hemodynamic and cardiac remodeling, in spontaneously hypertensive rats (SHRs) that display a diastolic dysfunction with preserved ejection fraction.

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