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Compaction of Duplex Nucleic Acids upon Native Electrospray Mass Spectrometry

Archive ouverte | Porrini, Massimiliano | CCSD

International audience. We report on the fate of nucleic acids conformation in the gas phase as sampled using native mass spectrometry coupled to ion mobility spectrometry. On the basis of several successful reports...

Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry

Archive ouverte | Abi-Ghanem, Josephine | CCSD

International audience. When electrosprayed from native solution conditions, RNA hairpins and kissing complexes acquire charge states at which they get significantly more compact in the gas phase than their initial ...

Electrostatics Explains the Position-Dependent Effect of G⋅U Wobble Base Pairs on the Affinity of RNA Kissing Complexes

Archive ouverte | Abi‐ghanem, Josephine | CCSD

International audience. In the RNA realm, non‐Watson Crick base pairs are abundant and affect either the RNA 3D structure and/or its function. Here we investigated the formation of RNA kissing complexes where the lo...

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