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Selective bile canalicular changes induced by cholestatic drugs

Archive ouverte | Burbank, M. | CCSD

International audience. Many drugs have been reported to induce cholestasis in a dose-dependent or independent (idiosyncratic) manner. Intrahepatic cholestasis represents around 40% of drug-induced injuries and up t...

Changes in bile acid profiles induced by cholestatic drugs in HepaRG hepatocytes cultured in bile acid-enriched medium

Archive ouverte | Guillouzo, A. | CCSD

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Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

Archive ouverte | Burban, A. | CCSD

International audience. Endoplasmic reticulum (ER) stress has been associated with various drug–induced liver lesions but its participation in drug-induced cholestasis remains unclear. We first aimed at analyzing li...

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