Afficher la couverture 'Antiproliferative Activity of trans-Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells | Cebrian-Torrejon, Gerardo' en grand format
/5

0 avis

Antiproliferative Activity of trans-Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells

Archive ouverte

Cebrian-Torrejon, Gerardo | Kahn, Suzana Assad | Lagarde, Nathalie | Castellano, Flavia | Leblanc, Karine | Rodrigo, Jordi | Molinier-Frenkel, Valerie | Arias, Antonieta Rojas, De | Ferreira, Maria Elena | Thirant, Cecile | Fournet, Alain | Figadere, Bruno | Chneiweiss, Herve | Poupon, Erwan

Edité par CCSD ; American Chemical Society -

International audience. Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.

Consulter en ligne

Suggestions

Du même auteur

The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum

Archive ouverte | Cebrian-Torrejon, Gerardo, Cebrian | CCSD

International audience. Zanthoxylum chiloperone var. angustifolium Engl., Rutaceae, is used in traditional medicine to treat fungal and protozoal infections in the central area of South America. Considering the incr...

Carbonylhydrazide-Based Molecular Tongs Inhibit Wild-Type and Mutated HIV-1 Protease Dimerization

Archive ouverte | Dufau, Laure | CCSD

International audience. We have designed and synthesized new molecular tongs based on a rigid naphthalene scaffold and evaluated their antidimer activity on HIV-1 protease (PR). We inserted carbonylhydrazide and oli...

Differential Proteomic Analysis of Human Glioblastoma and Neural Stem Cells Reveals HDGF as a Novel Angiogenic Secreted Factor

Archive ouverte | Thirant, Cecile | CCSD

International audience. Presence in glioblastomas of cancer cells with normal neural stem cell (NSC) properties, tumor initiating capacity, and resistance to current therapies suggests that glioblastoma stem-like ce...

Chargement des enrichissements...