Afficher la couverture 'Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance | Jeitany, Maya' en grand format
/5

0 avis

Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance

Archive ouverte

Jeitany, Maya | Bakhos-Douaihy, Dalal | Silvestre, David C. | Pineda, Jose R. | Ugolin, Nicolas | Moussa, Angela | Gauthier, Laurent R. | Busso, Didier | Junier, Marie-Pierre | Chneiweiss, Herve | Chevillard, Sylvie | Desmaze, Chantal | Boussin, Francois D.

Edité par CCSD ; Impact journals -

International audience. Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SAGA-like complexes. Here, we reveal that down regulation of GCN5 and PCAF had differential effects on some phenotypic characteristics of ALT cells. Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells.

Consulter en ligne

Suggestions

Du même auteur

ALT cancer cells are specifically sensitive to lysine acetyl transferaseinhibition

Archive ouverte | Bakhos-Douaihy, Dalal | CCSD

International audience. Some cancer cells elongate their telomeres through the ALT (alternative lengthening of telomeres) pathway, which is based on homologous recombination for the addition of telomere repeats with...

A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)

Archive ouverte | Jeitany, Maya | CCSD

International audience. Glioblastoma multiforme is the most aggressive primary tumor of the central nervous system. Glioma stem cells (GSCs), a small population of tumor cells with stem-like properties, are supposed...

Peptide nucleic acid–nanodiamonds: covalent and stable conjugates for DNA targeting

Archive ouverte | Gaillard, Claire | CCSD

International audience. This article highlights our recent application of functional nanodiamonds (NDs) with peptide nucleic acids (PNA) to develop tools for DNA detection. NDs appear as an ideal nanocarrier due to ...

Chargement des enrichissements...