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Endothelio-Mesenchymal Interaction Controls runx1 Expression and Modulates the notch Pathway to Initiate Aortic Hematopoiesis

Archive ouverte | Richard, Charlotte | CCSD

International audience. Hematopoietic stem cells (HSCs) are produced by a small cohort of hemogenic endothelial cells (ECs) during development through the formation of intra-aortic hematopoietic cell (HC) clusters. ...

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Archive ouverte | Jaffredo, Thierry | CCSD

International audience. The embryonic dorsal aorta plays a pivotal role in the production of the first hematopoietic stem cells (HSCs), the founders of the adult hematopoietic system. HSC production is polarized by ...

A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche

Archive ouverte | Miladinovic, Olivera | CCSD

International audience. The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of the mid-gestation mouse embryo. However, the precise nature of their supportive...

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