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Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

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Lallement, Pierre-Alexandre | Meux, Edgar | Gualberto, José M. | Dumarcay, Stéphane | Favier, Frédérique | Didierjean, Claude | Saul, Frederick | Haouz, Ahmed | Rouhier, Mélanie | Gelhaye, Éric | Rouhier, Nicolas | Hecker, Arnaud

Edité par CCSD ; Wiley -

International audience. Glutathionyl-hydroquinone reductases (GHRs) catalyze the deglutathionylation of quinones via a catalytic cysteine. The two GHR genes in the Populus trichocarpa genome, Pt-GHR1 and Pt-GHR2, are primarily expressed in reproductive organs. Both proteins are localized in plastids. More specifically, Pt-GHR2 localizes in nucleoids. At the structural level, Pt-GHR1 adopts a typical GHR fold, with a dimerization interface comparable to that of the bacterial and fungal GHR counterparts. Pt-GHR1 catalyzes the deglutathionylation of both reduced and oxidized glutathionylated quinones, but the enzyme is more catalytically efficient with the reduced forms.

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