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Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice

Archive ouverte | Blanchard, Claire | CCSD

IF 3.947. International audience. BACKGROUND: Increased lipopolysaccharide (LPS) translocation due to altered intestinal permeability has been suggested as a mechanism for obesity-associated insulin resistance. The ...

PCSK9 is not secreted from mature differentiated intestinal cells

Archive ouverte | Moreau, François | CCSD

International audience. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes lysosomal degradation of the LDL receptor and is a key regulator of cholesterol metabolism. After the liver, the small intestine...

Roux-en-Y gastric bypass reduces plasma cholesterol in diet-induced obese mice by affecting trans-intestinal cholesterol excretion and intestinal cholesterol absorption

Archive ouverte | Blanchard, Claire | CCSD

International audience. OBJECTIVE: Bariatric surgery appears as the most efficient therapeutic alternative in morbidly obese patients. In addition to its efficiency to decrease body weight, it also improves metaboli...

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