RNA sequencing analysis of Celf1 mouse mutants identifies a cohort of abnormally expressed lens development regulators

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Siddam, Archana D. | Anand, Deepti | Paillard, Luc | Lachke, Salil Anil

Edité par CCSD ; Association for Research in Vision and Ophthalmology -

International audience. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA, MAY 01-05, 2016

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High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology

Archive ouverte | Siddam, Archana D. | CCSD

International audience. Defects in the development of the ocular lens can cause congenital cataracts. To understand the various etiologies of congenital cataracts, it is important to characterize the genes linked to...

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Archive ouverte | Aryal, Sandeep | CCSD

International audience. The homeodomain transcription factors (TFs) Pax6 (OMIM 607108) and Prox1 (OMIM 601546) critically regulate gene expression in lens development. While PAX6 mutations in humans can cause catara...

The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development

Archive ouverte | Siddam, Archana, D | CCSD

International audience. Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, pre...

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