Syracuse

Immediate perception of a reward is distinct from the reward's long-term salience

Archive ouverte

Mcginnis, John P. | Jiang, Huoqing | Agha, Moutaz Ali | Sanchez, Consuelo Perez | Lange, Jeff | Yu, Zulin | Marion-Poll, Frederic | Si, Kausik

Edité par CCSD ; eLife Sciences Publication -

WOS:000393392800001. International audience. Reward perception guides all aspects of animal behavior. However, the relationship between the perceived value of a reward, the latent value of a reward, and the behavioral response remains unclear. Here we report that, given a choice between two sweet and chemically similar sugarsL- and D-arabinoseDrosophila melanogaster prefers D- over L- arabinose, but forms long-term memories of L-arabinose more reliably. Behavioral assays indicate that L-arabinose-generated memories require sugar receptor Gr43a, and calcium imaging and electrophysiological recordings indicate that L- and D-arabinose differentially activate Gr43a-expressing neurons. We posit that the immediate valence of a reward is not always predictive of the long-term reinforcement value of that reward, and that a subset of sugar-sensing neurons may generate distinct representations of similar sugars, allowing for rapid assessment of the salient features of various sugar rewards and generation of reward-specific behaviors. However, how sensory neurons communicate information about L-arabinose quality and concentrationfeatures relevant for long-term memoryremains unknown.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion