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Role of HIF-1α in both resistance to photon and carbon ion irradiations and invasiveness of Head and Neck Squamous Cell Carcinoma (HNSCC) cancer stem cells

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Wozny, Anne-Sophie

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Séminaire invité au National Institute of Radiological Sciences (NIRS), Chiba, Japon

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Specific molecular mechanisms of the carbon ion irradiation response in HNSCC (Cancer Stem Cells and non-Cancer Stem Cells). Mécanismes moléculaires spécifiques de la réponse aux ions carbone dans les cellules tumorales (souches et non souches) des cancers des Voies Aéro-Digestives Supérieures

Archive ouverte | Wozny, Anne-Sophie | CCSD

Hadrontherapy using carbon ions is an alternative to photon irradiation in the treatment of Head and Neck cancers, because of accurate ballistics and high biological efficiency, including hypoxic tumor areas. These cancers are of ...

Role of HIF-1α in the resistance of Cancer Stem Cells to photon and carbon ion irradiations

Archive ouverte | Wozny, Anne-Sophie | CCSD

International audience. Head-and-Neck-Squamous Cell Carcinoma (HNSCC) are resistant to standard treatments, partly due to Cancer Stem Cells (CSCs) localized in hypoxic niches. The protein HIF-1α (Hypoxia-Inducible F...

The ‘stealth-bomber’ paradigm for deciphering the tumour response to carbon-ion irradiation

Archive ouverte | Wozny, Anne-Sophie | CCSD

International audience. Numerous studies have demonstrated the higher biological efficacy of carbon-ion irradiation (C-ions) and their ballistic precision compared with photons. At the nanometre scale, the reactive ...

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