Antimicrobials: a global alliance for optimizing their rational use in ă intra-abdominal infections (AGORA)
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Ă Curcio, Daniel | Delibegovic, Samir | Demetrashvili, Zaza | de Ă Simone, Belinda | Dhingra, Sameer | Diaz, Jose J. | Di Carlo, Ă Isidoro | Dillip, Angel | Di Saverio, Salomone | Doyle, Michael P. Ă | Dorj, Gereltuya | Dogjani, Agron | Dupont, Hervé | Eachempati, Ă Soumitra R. | Enani, Mushira Abdulaziz | Egiev, Valery N. | Ă Elmangory, Mutasim M. | Ferrada, Paula | Fitchett, Joseph R. | Ă Fraga, Gustavo P. | Guessennd, Nathalie | Giamarellou, Helen | Ă Ghnnam, Wagih | Gkiokas, George | Goldberg, Staphanie R. | Gomes, Ă Carlos Augusto | Gomi, Harumi | Guzman-Blanco, Manuel | Haque, Ă Mainul | Hansen, Sonja | Hecker, Andreas | Heizmann, Wolfgang R. Ă | Herzog, Torsten | Hodonou, Adrien Montcho | Hong, Suk-Kyung | Ă Kafka-Ritsch, Reinhold | Kaplan, Lewis J. | Kapoor, Garima | Ă Karamarkovic, Aleksandar | Kees, Martin G. | Kenig, Jakub | Ă Kiguba, Ronald | Kim, Peter K. | Kluger, Yoram | Khokha, Vladimir Ă | Koike, Kaoru | Kok, Kenneth Y. Y. | Kong, Victory | Knox, Ă Matthew C. | Inaba, Kenji | Isik, Arda | Iskandar, Katia | Ă Ivatury, Rao R. | Labbate, Maurizio | Labricciosa, Francesco M. | Ă Laterre, Pierre-Francois | Latifi, Rifat | Lee, Jae Gil | Lee, Ă Young Ran | Leone, Marc | Leppaniemi, Ari | Li, Yousheng | Ă Liang, Stephen Y. | Loho, Tonny | Maegele, Marc | Malama, Sydney Ă | Marei, Hany E. | Martin-Loeches, Ignacio | Marwah, Sanjay | Ă Massele, Amos | Mcfarlane, Michael | Melo, Renato Bessa | Negoi, Ă Ionut | Nicolau, David P. | Nord, Carl Erik | Ofori-Asenso, Ă Richard | Omari, Abdelkarim H. | Ordonez, Carlos A. | Ouadii, Ă Mouaqit | Pereira Junior, Gerson Alves | Piazza, Diego | Pupelis, Ă Guntars | Rawson, Timothy Miles | Rems, Miran | Rizoli, Sandro | Ă Rocha, Claudio | Sakakhushev, Boris | Sanchez-Garcia, Miguel | Ă Sato, Norio | Lohse, Helmut A. Segovia | Sganga, Gabriele | Ă Siribumrungwong, Boonying | Shelat, Vishal G. | Soreide, Kjetil | Ă Soto, Rodolfo | Talving, Peep | Tilsed, Jonathan V. | Timsit, Ă Jean-Francois | Trueba, Gabriel | Trung, Ngo Tat | Ulrych, Jan | Goor, Harry, Ă Van | Vereczkei, Andras | Vohra, Ravinder S. | Wani, Ă Imtiaz | Uhl, Waldemar | Xiao, Yonghong | Yuan, Kuo-Ching | Ă Zachariah, Sanoop K. | Zahar, Jean-Ralph | Zakrison, Tanya L. | Ă Corcione, Antonio | Melotti, Rita M. | Viscoli, Claudio | Viale, Ă Perluigi | Sartelli, Massimo | Weber, Dieter G. | Ruppe, Etienne | Bassetti, Ă Matteo | Wright, Brian J. | Ansaloni, Luca | Catena, Fausto | Ă Coccolini, Federico | Abu-Zidan, Fikri M. | Coimbra, Raul | Moore, Ă Ernest E. | Moore, Frederick A. | Maier, Ronald V. | de Waele, Jan Ă J. | Kirkpatrick, Andrew W. | Griffiths, Ewen A. | Eckmann, Ă Christian | Brink, Adrian J. | Mazuski, John E. | May, Addison K. Ă | Sawyer, Rob G. | Mertz, Dominik | Montravers, Philippe | Ă Kumar, Anand | Roberts, Jason A. | Vincent, Jean-Louis | Watkins, Ă Richard R. | Lowman, Warren | Spellberg, Brad | Abbott, Iain J. Ă | Adesunkanmi, Abdulrashid Kayode | Al-Dahir, Sara | Al-Hasan, Ă Majdi N. | Agresta, Ferdinando | Althani, Asma A. | Ansari, Ă Shamshul | Ansumana, Rashid | Augustin, Goran | Bala, Miklosh | Ă Balogh, Zsolt J. | Baraket, Oussama | Bhangu, Aneel | Beltran, Ă Marcelo A. | Bernhard, Michael | Biffl, Walter L. | Boermeester, Ă Marja A. | Brecher, Stephen M. | Cherry-Bukowiec, Jill R. | Buyne, Ă Otmar R. | Cainzos, Miguel A. | Cairns, Kelly A. | Camacho-Ortiz, Ă Adrian | Chandy, Sujith J. | Jusoh, Asri Che | Chichom-Mefire, Ă Alain | Colijn, Caroline | Corcione, Francesco | Cui, Yunfeng
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CCSD ; BioMed Central -
International audience.
Intra-abdominal infections (IAI) are an important cause of morbidity and ă are frequently associated with poor prognosis, particularly in high-risk ă patients. ă The cornerstones in the management of complicated IAIs are timely ă effective source control with appropriate antimicrobial therapy. Empiric ă antimicrobial therapy is important in the management of intra-abdominal ă infections and must be broad enough to cover all likely organisms ă because inappropriate initial antimicrobial therapy is associated with ă poor patient outcomes and the development of bacterial resistance. ă The overuse of antimicrobials is widely accepted as a major driver of ă some emerging infections (such as C. difficile), the selection of ă resistant pathogens in individual patients, and for the continued ă development of antimicrobial resistance globally. The growing emergence ă of multi-drug resistant organisms and the limited development of new ă agents available to counteract them have caused an impending crisis with ă alarming implications, especially with regards to Gram-negative ă bacteria. ă An international task force from 79 different countries has joined this ă project by sharing a document on the rational use of antimicrobials for ă patients with IAIs. The project has been termed AGORA (Antimicrobials: A ă Global Alliance for Optimizing their Rational Use in Intra-Abdominal ă Infections). The authors hope that AGORA, involving many of the world's ă leading experts, can actively raise awareness in health workers and can ă improve prescribing behavior in treating IAIs.
