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Mouse genetic background impacts both on iron and non-iron metals parameters and on their relationships

Archive ouverte | Cavey, Thibault | CCSD

International audience. Iron is reported to interact with other metals. In addition, it has been shown that genetic background may impact iron metabolism. Our objective was to characterize, in mice of three genetic ...

GATA-4 transcription factor regulates hepatic hepcidin expression.

Archive ouverte | Island, Marie-Laure | CCSD

International audience. Hepcidin, an hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability. Thus, by inducing the internalization of the iron exporter ferroportin, it regula...

Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice

Archive ouverte | Cavey, Thibault | CCSD

International audience. Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator, that favors the iron sequestration in the spleen. Genetic iron overload related to hepcidin i...

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