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Hydrogenated diglucose detergents for membrane-protein extraction and stabilization

Archive ouverte | Guillet, Pierre | CCSD

International audience. We report herein the design and synthesis of a novel series of alkyl glycosides detergents consisting of a nonionic polar headgroup that comprises two glucose moieties in a branched arrangeme...

New amphiphiles to handle membrane proteins: "ménage à trois" between chemistry, physical chemistry and biochemistry.

Archive ouverte | Durand, Grégory | CCSD

International audience. To perform biochemical and structural studies of membrane proteins (MPs), amphiphilic molecules that mimic the hydrophobic environment of lipids are required. Over the past decades, detergent...

Small angle neutron scattering for the study of solubilised membrane proteins.

Archive ouverte | Breyton, Cécile | CCSD

International audience. Small angle neutron scattering (SANS) is a powerful technique for investigating association states and conformational changes of biological macromolecules in solution. SANS is of particular i...

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