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Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection

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Ramful, Duksha | Samperiz, Sylvain | Fritel, Xavier | Michault, Alain | Jaffar-Bandjee, Marie-Christine | Rollot, Olivier | Boumahni, Brahim | Gérardin, Patrick

Edité par CCSD ; Oxford University Press -

International audience. To search for serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort study (Reunion island, 2006-2008). CHIKV-specific antibody kinetics showed no evidence of asymptomatic congenital infection as neonates were tested negative for CHIKV-specific IgM antibodies at birth and 368 infants with CHIKV-specific IgG antibodies seroreversed completely (mean seroreversion time: 7.7 months). Seroreversion time of transplacental CHIKV IgG antibodies was inversely correlated with the stage of pregnancy at which exposure took place and end-term small for gestational infants seroreversed earlier.

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