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The pVHL172 isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13

Archive ouverte | Hascoet, Pauline | CCSD

International audience. The von Hippel-Lindau () tumor suppressor gene is often deleted or mutated in ccRCC (clear cell renal cell carcinoma) producing a non-functional protein. The gene encodes two mRNA, and three ...

The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation

Archive ouverte | Chesnel, Franck | CCSD

International audience. Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regul...

Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel-Lindau tumor suppressor protein

Archive ouverte | Le Goff, Xavier | CCSD

International audience. Quality control mechanisms promote aggregation and degradation of misfolded proteins. In budding yeast, the human von Hippel-Lindau protein (pVHL, officially known as VHL) is misfolded and fo...

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