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Differential exoproteome analysis of two [i]Corynebacterium pseudotuberculosis[/i] biovar [i]ovis[/i] strains isolated from goat (1002) and sheep (C231)

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Silva, Wanderson M | Seyffert, Nubia | Ciprandi, Allessandra | Santos, Agenor V | Castro, Thiago L P | Pacheco, Luis G C | Barh, Debmalya | Le Loir, Yves | Pimenta, Adriano M C | Miyoshi, Anderson | Silva, Artur | Azevedo, Vasco

Edité par CCSD ; Springer Verlag -

[i]Corynebacterium pseudotuberculosis[/i] is the etiologic agent of caseous lymphadenitis a chronic infectious disease affecting small ruminants. The 2D-DIGE technique was used to compare the exoproteomes of two [i]C. pseudotuberculosis[/i] biovar [i]ovis[/i] strains isolated from goat (strain 1002) and sheep (strain C231). Seventeen proteins differentially produced were identified here. Nine proteins appeared over-produced in the exoproteome of 1002 goat strain and 8 in that of C231 sheep strain. These proteins were related to various biological functions, such as the cell envelope, respiratory metabolism and proteolysis. This proteomic analysis revealed strain-specific exoproteins although each of the corresponding genes was found in both strain genomes. Such differential expression pattern may reflect inter-strain differences in adaptation to a specific host, in pathogenicity and or in antigenicity of this pathogenic bacterium.

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