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High-chloride concentrations abolish the binding of adenine nucleotides in the mitochondrial ADP/ATP carrier family.

Archive ouverte | Krammer, Eva-Maria | CCSD

International audience. The ADP/ATP carrier (AAC) is a very effective membrane protein that mediates the exchange of ADP and ATP across the mitochondrial membrane. In vivo transport measurements on the AAC overexpre...

Impaired transport of nucleotides in a mitochondrial carrier explains severe human genetic diseases.

Archive ouverte | Ravaud, Stéphanie | CCSD

International audience. The mitochondrial ADP/ATP carrier (AAC) is a prominent actor in the energetic regulation of the cell, importing ADP into the mitochondria and exporting ATP toward the cytoplasm. Severe geneti...

The substrate specificity of the human ADP/ATP carrier AAC1.

Archive ouverte | Mifsud, John | CCSD

International audience. The mitochondrial ADP/ATP carrier imports ADP from the cytosol into the mitochondrial matrix for its conversion to ATP by ATP synthase and exports ATP out of the mitochondrion to replenish th...

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