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MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

Archive ouverte | Mallilankaraman, Karthik | CCSD

International audience. Ca(2+) flux across the mitochondrial inner membrane regulates bioenergetics, cytoplasmic Ca(2+) signals and activation of cell death pathways. Mitochondrial Ca(2+) uptake occurs at regions of...

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Archive ouverte | Mallilankaraman, Karthik | CCSD

International audience. Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable voltage present across the inner memb...

Essential Regulation of Cell Bioenergetics by Constitutive InsP(3) Receptor Ca(2+) Transfer to Mitochondria.

Archive ouverte | Cárdenas, César | CCSD

International audience. Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP. Nevertheless, regulati...

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