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Mechanistic studies of Gd$^{3+}$-based MRI contrast agents for Zn$^{2+}$ detection: towards rational design

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Bonnet, Célia S. | Caillé, Fabien | Pallier, Agnès | Morfin, Jean-François | Petoud, Stéphane | Suzenet, Franck | Tóth, Éva

Edité par CCSD ; Wiley-VCH Verlag -

International audience. A series of novel pyridine-based Gd$^{3+}$ complexes have been prepared and studied as potential MRI contrast agents for Zn$^{2+}$ detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn$^{2+}$ binding in terms of variations of the rotational motion.

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