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European Gene Mapping Project (EUROGEM): breakpoint panels for human chromosomes based on the CEPH reference families. Centre d'Etude du Polymorphisme Humain.

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Cox, S A | Attwood, J | Bryant, S P | Bains, R | Povey, S | Rebello, M | Kapsetaki, M | Moschonas, N K | Grzeschik, K H | Otto, M | Dixon, M | Sudworth, H E | Kooy, R F | Wright, A | Teague, P | Terrenato, L | Vergnaud, Gilles | Monfouilloux, S | Weissenbach, J | Alibert, O | Dib, C | Fauré, S | Bakker, E | Pearson, Nathaniel M. | Spurr, N K

Edité par CCSD ; Wiley -

International audience. Meiotic breakpoint panels for human chromosomes 2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 17, 18, 20 and X were constructed from genotypes from the CEPH reference families. Each recombinant chromosome included has a breakpoint well-supported with reference to defined quantitative criteria. The panels were constructed at both a low-resolution, useful for a first-pass localization, and high-resolution, for a more precise placement. The availability of such panels will reduce the number of genotyping experiments necessary to order new polymorphisms with respect to existing genetic markers. This paper shows only a representative sample of the breakpoints detected. The complete data are available on the World Wide Web (URL http:/(/)www.icnet.uk/axp/hgr/eurogem++ +/HTML/data.html) or by anonymous ftp (ftp.gene.ucl.ac.uk in/pub/eurogem/maps/breakpoints).

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