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Polymodal activation of the endocannabinoid system in the extended amygdala.

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Puente, Nagore | Cui, Yihui | Lassalle, Olivier | Lafourcade, Mathieu | Georges, François | Venance, Laurent | Grandes, Pedro | Manzoni, Olivier J

Edité par CCSD ; Nature Publishing Group -

International audience. The reason why neurons synthesize more than one endocannabinoid (eCB) and how this is involved in the regulation of synaptic plasticity in a single neuron is not known. We found that 2-arachidonoylglycerol (2-AG) and anandamide mediate different forms of plasticity in the extended amygdala of rats. Dendritic L-type Ca(2+) channels and the subsequent release of 2-AG acting on presynaptic CB1 receptors triggered retrograde short-term depression. Long-term depression was mediated by postsynaptic mGluR5-dependent release of anandamide acting on postsynaptic TRPV1 receptors. In contrast, 2-AG/CB1R-mediated retrograde signaling mediated both forms of plasticity in the striatum. These data illustrate how the eCB system can function as a polymodal signal integrator to allow the diversification of synaptic plasticity in a single neuron.

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