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A Sulfur Tripod Glycoconjugate that Releases a High-Affinity Copper Chelator in Hepatocytes

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Pujol, Anais M | Cuillel, Martine | Jullien, Anne-Solène | Lebrun, Colette | Cassio, Doris | Mintz, Elisabeth | Gateau, Christelle | Delangle, Pascale

Edité par CCSD ; Wiley-VCH Verlag -

International audience. Released in the cell: Three N-acetylgalactosamine units, which recognize the asialoglycoprotein receptor, were tethered through disulfide bonds to the three coordinating thiol functions of a sulfur tripod ligand that has a high affinity for CuI (see scheme). The resulting glycoconjugate can be considered as a prodrug, because after uptake by hepatic cells the intracellular reducing glutathione (GSH) releases the high-affinity intracellular CuI chelator.

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