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PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans.

Archive ouverte | Grall, Anaïs | CCSD

International audience. Ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal desquamation over the whole body, for which the genetic causes of several human forms remain unknown. We ...

A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies

Archive ouverte | Plassais, Jocelyn | CCSD

International audience. Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds are partic...

Characterisation and functional predictions of canine long non-coding RNAs

Archive ouverte | Le Beguec, Celine | CCSD

International audience. Long non-coding RNAs (lncRNAs) are a family of heterogeneous RNAs that play major roles in multiple biological processes. We recently identified an extended repertoire of more than 10,000 lnc...

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