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Contrasting facets of nanoparticles-based phototherapy : photo-damage and photo-regeneration

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Garrier, Julie | Reshetov, Vadzim | Zorin, Vladimir | Guillemin, François | Bezdetnaya, Lina

Edité par CCSD ; Nova Science Publishers -

International audience. The present review describes two different applications of the phototherapy. The first one referred as Photodynamic Therapy (PDT) is widely used for pathologically proliferated tissues, including cancer. PDT is based on the combined action of three parameters: photosensitizer, light and oxygen, resulting in the production of toxic reactive oxygen species. To improve the selectivity of phosensitizers for pathological tissues the liposomal photosensitizers formulations have been proposed favoring tumor targeting. The comprehension of the mechanisms that govern the drug release processes of photosensitizers in liposomal nanostructures and as such their pharmacokinetics behavior is essential and is addressed in the present review. Another facet of nanoparticles-based photoinduced therapy is related to tissue regeneration. Complex mechanisms of photoinduced wound healing and repair will be considered, including the role of different cell types, growth factors and antimicrobial action. In conclusion, PDT offers two contrasting strategies either to eradicate pathological tissues or to stimulate tissue repair. In fine, consideration of all parameters involved in this kind of phototherapy is required to obtain a desired effect and optimize clinical protocols.

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