X-ray-Induced singlet oxygen activation with nanoscintillator-coupled porphyrins

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Bulin, Anne-Laure | Truillet, Charles | Chouikrat, Rima | Lux, François | Frochot, Céline | Amans, David | Ledoux, Gilles | Tillement, Olivier | Perriat, Pascal | Barberi-Heyob, Muriel | Dujardin, Christophe

Edité par CCSD ; American Chemical Society -

International audience. Tb2O3 coated with a polysiloxane layer is a biocompatible nanoscintillator that exhibits an appropriate pattern of biodistribution after injection. In this contribution, we combine this nanosystem with porphyrin molecules that are able to generate singlet oxygen, a major cytotoxic agent for photodynamic therapy application. Using time-resolved laser spectroscopy and singlet oxygen probes, we demonstrate this combination is suitable for singlet oxygen generation induced by X-ray and provide a physical study of the energy transfer observed between the nanoscintillator and the porphyrin. Combined with a radiotherapy protocol, the proposed nanohybrid system presents a combination of physical, chemical, and biological properties that make it a good candidate for photodynamic effects in deep tissues.

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