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Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activities.

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Lalut, Julien | Tripoteau, Ludovic | Marty, Christel | Bares, Hugo | Bourgougnon, Nathalie | Felpin, François-Xavier

Edité par CCSD ; Elsevier -

International audience. A series of 3-deazauridines (3-DU) analogues were synthesized and evaluated in vitro for their antiherpetic activity against HSV-1 on Vero cell lines by cell viability. A first campaign of tests suggested that C3-arylated-3-DU derivatives could constitute a novel family of antiherpetic agents. A second campaign of biological evaluations led to the discovery of two potent anti-HSV-1 agents with comparable activity than acyclovir.

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