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Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia.

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Navas, Maria-Cristina | Suarez, Iris | Carreño, Andrea | Uribe, Diego | Rios, Wilson Alfredo | Cortes-Mancera, Fabian | Martel, Ghyslaine | Vieco, Beatriz | Lozano, Diana | Jimenez, Carlos | Gouas, Doriane | Osorio, German | Hoyos, Sergio | Restrepo, Juan Carlos | Correa, Gonzalo | Jaramillo, Sergio | Lopez, Rocio | Bravo, Luis Eduardo | Arbelaez, Maria Patricia | Scoazec, Jean-Yves | Abedi-Ardekani, Behnoush | Santella, Regina M | Chemin, Isabelle | Hainaut, Pierre

Edité par CCSD ; Hindawi Publishing Corporation -

International audience. Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection.

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