Long-term follow-up of the imatinib GRAAPH-2003 study in newly diagnosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL study.

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Tanguy-Schmidt, Aline | Rousselot, Philippe | Chalandon, Yves | Cayuela, Jean-Michel | Hayette, Sandrine | Vekemans, Marie-Christiane | Escoffre, Martine | Huguet, Françoise | Réa, Delphine | Delannoy, André | Cahn, Jean-Yves | Vernant, Jean-Paul | Ifrah, Norbert | Dombret, Hervé | Thomas, Xavier

Edité par CCSD ; Elsevier -

International audience. We report here the results of the GRAAPH-2003 trial with long-term follow-up in 45 patients with de novo Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Imatinib-based strategy improved the 4-year overall survival (OS) up to 52% versus 20% in the pre-imatinib LALA-94 trial (P = .0001). Despite the selection in patients who actually underwent transplantation, these results suggest that allogeneic or autologous stem cell transplants (SCTs) still have a place in overcoming the poor prognosis of Ph+ ALL in the era of imatinib therapy. OS was 50% after allogeneic SCT (24 patients), 33% in patients without a transplantation (9 patients), and 80% after autologous SCT (10 patients without allogeneic donor or >55 years, including 7 patients in complete molecular response).

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