The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones.

Archive ouverte

Norais, Cédric | Servant, Pascale | Bouthier de La Tour, Claire | Coureux, Pierre-Damien | Ithurbide, Solenne | Vannier, Françoise | Guerin, Philippe P | Dulberger, Charles L | Satyshur, Kenneth A | Keck, James L | Armengaud, J. | Cox, Michael M | Sommer, Suzanne

Edité par CCSD ; Public Library of Science -

International audience. The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion