Syracuse

The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action.

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Biot, Christophe | Castro, William | Botté, Cyrille y | Navarro, Maribel

Edité par CCSD ; Royal Society of Chemistry -

International audience. Despite recent encouraging advances against the disease, malaria remains a major public health problem affecting almost half a billion people and killing almost a million per annum. Due to a short arsenal of efficient antimalarial agents and the frequent appearance of resistance to the drugs in current use, which consequently reduce our means to treat patients, there is a very urgent and continuous need to develop new compounds. This perspective outlines a unique strategy for that purpose through the development of metal-based antimalarial agents. The examples presented here illustrate an attractive alternative to classical drugs.

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