The B73 maize genome: complexity, diversity, and dynamics.
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Schnable, Patrick S | Ware, Doreen | Fulton, Robert S | Stein, Joshua C | Wei, Fusheng | Pasternak, Shiran | Liang, Chengzhi | Zhang, Jianwei | Fulton, Lucinda | Graves, Tina A | Minx, Patrick | Reily, Amy Denise | Courtney, Laura | Kruchowski, Scott S | Tomlinson, Chad | Strong, Cindy | Delehaunty, Kim | Fronick, Catrina | Courtney, Bill | Rock, Susan M | Belter, Eddie | Du, Feiyu | Kim, Kyung | Abbott, Rachel M | Cotton, Marc | Levy, Andy | Marchetto, Pamela | Ochoa, Kerri | Jackson, Stephanie M | Gillam, Barbara | Chen, Weizu | Yan, Le | Higginbotham, Jamey | Cardenas, Marco | Waligorski, Jason | Applebaum, Elizabeth | Phelps, Lindsey | Falcone, Jason | Kanchi, Krishna | Thane, Thynn | Scimone, Adam | Thane, Nay | Henke, Jessica | Wang, Tom | Ruppert, Jessica | Shah, Neha | Rotter, Kelsi | Hodges, Jennifer | Ingenthron, Elizabeth | Cordes, Matt | Kohlberg, Sara | Sgro, Jennifer | Delgado, Brandon | Mead, Kelly | Chinwalla, Asif | Leonard, Shawn | Crouse, Kevin | Collura, Kristi | Kudrna, Dave | Currie, Jennifer | He, Ruifeng | Angelova, Angelina | Rajasekar, Shanmugam | Mueller, Teri | Lomeli, Rene | Scara, Gabriel | Ko, Ara | Delaney, Krista | Wissotski, Marina | Lopez, Georgina | Campos, David | Braidotti, Michele | Ashley, Elizabeth | Golser, Wolfgang | Kim, Hyeran | Lee, Seunghee | Lin, Jinke | Dujmic, Zeljko | Kim, Woojin | Talag, Jayson | Zuccolo, Andrea | Fan, Chuanzhu | Sebastian, Aswathy | Kramer, Melissa | Spiegel, Lori | Nascimento, Lidia | Zutavern, Theresa | Miller, Beth | Ambroise, Claude | Muller, Stephanie | Spooner, Will | Narechania, Apurva | Ren, Liya | Wei, Sharon | Kumari, Sunita | Faga, Ben | Levy, Michael J | Mcmahan, Linda | van Buren, Peter | Vaughn, Matthew W | Ying, Kai | Yeh, Cheng-Ting | Emrich, Scott J | Jia, Yi | Kalyanaraman, Ananth | Hsia, An-Ping | Barbazuk, W Brad | Baucom, Regina S | Brutnell, Thomas P | Carpita, Nicholas C | Chaparro, Cristian | Chia, Jer-Ming | Deragon, Jean-Marc | Estill, James C | Fu, Yan | Jeddeloh, Jeffrey A | Han, Yujun | Lee, Hyeran | Li, Pinghua | Lisch, Damon R | Liu, Sanzhen | Liu, Zhijie | Nagel, Dawn Holligan | Mccann, Maureen C | Sanmiguel, Phillip | Myers, Alan M | Nettleton, Dan | Nguyen, John | Penning, Bryan W | Ponnala, Lalit | Schneider, Kevin L | Schwartz, David C | Sharma, Anupma | Soderlund, Carol | Springer, Nathan M | Sun, Qi | Wang, Hao | Waterman, Michael | Westerman, Richard | Wolfgruber, Thomas K | Yang, Lixing | Yu, Yeisoo | Zhang, Lifang | Zhou, Shiguo | Zhu, Qihui | Bennetzen, Jeffrey L | Dawe, R Kelly | Jiang, Jiming | Jiang, Ning | Presting, Gernot G | Wessler, Susan R | Aluru, Srinivas | Martienssen, Robert A | Clifton, Sandra W | Mccombie, W Richard | Wing, Rod A | Wilson, Richard K
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CCSD ; American Association for the Advancement of Science (AAAS) -
International audience.
We report an improved draft nucleotide sequence of the 2.3-gigabase genome of maize, an important crop plant and model for biological research. Over 32,000 genes were predicted, of which 99.8% were placed on reference chromosomes. Nearly 85% of the genome is composed of hundreds of families of transposable elements, dispersed nonuniformly across the genome. These were responsible for the capture and amplification of numerous gene fragments and affect the composition, sizes, and positions of centromeres. We also report on the correlation of methylation-poor regions with Mu transposon insertions and recombination, and copy number variants with insertions and/or deletions, as well as how uneven gene losses between duplicated regions were involved in returning an ancient allotetraploid to a genetically diploid state. These analyses inform and set the stage for further investigations to improve our understanding of the domestication and agricultural improvements of maize.
- Indexation
- MESH: Base Sequence
- MESH: Centromere
- MESH: Genetic Variation
- MESH: Genome, Plant
- MESH: Inbreeding
- MESH: MicroRNAs
- MESH: Molecular Sequence Data
- MESH: Ploidies
- MESH: RNA, Plant
- MESH: Recombination, Genetic
- MESH: Retroelements
- MESH: Sequence Analysis, DNA
- MESH: Chromosome Mapping
- MESH: Zea mays
- MESH: Chromosomes, Plant
- MESH: Crops, Agricultural
- MESH: DNA Copy Number Variations
- MESH: DNA Methylation
- MESH: DNA Transposable Elements
- MESH: DNA, Plant
- MESH: Genes, Plant
- [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
- [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
- [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
- [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy
- [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]
- [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
- [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN]
- [SDV.BC]Life Sciences [q-bio]/Cellular Biology
- [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
- [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
- [SDV.BV.AP]Life Sciences [q-bio]/Vegetal Biology/Plant breeding
- [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics