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Non-susceptibility to tigecycline in enterococci from hospitalised patients, food products and community sources
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International audience. In this study, the in vitro activity of tigecycline against 1140 enterococci collected from humans, food products, animals and the environment in Portugal (1996-2008) was analysed. Ten isolates (seven and three spp.) non-susceptible to tigecycline (minimum inhibitory concentrations of 0.5-1.0mg/L), which were also resistant to tetracycline and minocycline, were mostly observed in samples collected before the introduction of tigecycline in the therapeutic arsenal. The isolates were recovered from hospitalised patients (=2; ST319/CC2 and ST34), healthy humans (=2; ST21/CC21), chicken meat (=1; ST260) as well as from two swine samples. The remaining isolates were also recovered from chicken meat (=1; ) and swine (=2; and spp.). Recovery of enterococcal isolates with reduced susceptibility to tigecycline among different reservoirs, including animals for food consumption, suggests that selection of tigecycline-resistant isolates by antibiotics other than tigecycline might occur in non-clinical settings.
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