Targeted inhibition of the hepatitis C internal ribosomal entry site genomic RNA with oligonucleotide conjugates.

Archive ouverte | Guerniou, Valérie | CCSD

International audience. Hepatitis C is a major public health concern, with an estimated 170 million people infected worldwide and an urgent need for new drug development. An attractive therapeutic approach is to pre...

Antiviral effect of ribonuclease conjugated oligodeoxynucleotides targeting the IRES RNA of the hepatitis C virus.

Archive ouverte | Gamble, Carly | CCSD

International audience. Hepatitis C virus (HCV) translation initiation is mediated by a highly structured and conserved RNA, termed the Internal Ribosome Entry Site (IRES), located at the 5'-end of its single strand...

Directed cleavage of the HCV IRES RNA by imidazole-conjugated oligonucleotides

Archive ouverte | Guerniou, Valérie | CCSD